You are reading the article Ai And Microchips: A Revolutionary Step Towards Drug Discovery updated in December 2023 on the website Cancandonuts.com. We hope that the information we have shared is helpful to you. If you find the content interesting and meaningful, please share it with your friends and continue to follow and support us for the latest updates. Suggested January 2024 Ai And Microchips: A Revolutionary Step Towards Drug Discovery
3Brain AG has recently announced a new technology that combines both microchips and artificial intelligence. The revolutionary duo holds the promise of changing the way drug candidates are selected on a preclinical level. This will enhance their chances of maximizing their success. Preclinical studies are deemed as the most vital for the proper and early identification of safety and efficacy issues. Despite the several improvements made in the area of drug delivery, it often fails because of limited drawbacks in preclinical tests on animal models. Another major drawback is that drugs that work successfully on animals, fail to perform on humans later. In order to counter the ever-pervasive issues in drug delivery, new biotechnologies are introduced. New biotechnologies can resemble and perform like human stem cells are deemed as successful alternatives to animal models. These structures are made from a combination of AI and microchips in the form of cell culture and organoid assays that can be used for testbeds for drugs. These cell-based assays are revolutionizing drug development.
The Paradigm Disruption: A Transition from Traditional to BiotechnologicalMedical experts and doctors have expressed their discontentment about the traditional methods of drug delivery. Imbued with several limitations, the traditional methods of drug delivery failed to act in long bandwidths. From the standpoint of sustainability and affordability, traditional plastic multi-well plates are turned into intelligent devices with multi-core processing power. These devices can be programmed and updated from time to time.
3Brain AG has recently announced a new technology that combines both microchips and artificial intelligence. The revolutionary duo holds the promise of changing the way drug candidates are selected on a preclinical level. This will enhance their chances of maximizing their success. Preclinical studies are deemed as the most vital for the proper and early identification of safety and efficacy issues. Despite the several improvements made in the area of drug delivery, it often fails because of limited drawbacks in preclinical tests on animal models. Another major drawback is that drugs that work successfully on animals, fail to perform on humans later. In order to counter the ever-pervasive issues in drug delivery, new biotechnologies are introduced. New biotechnologies can resemble and perform like human stem cells are deemed as successful alternatives to animal models. These structures are made from a combination of AI and microchips in the form of cell culture and organoid assays that can be used for testbeds for drugs. These cell-based assays are revolutionizing drug development.Medical experts and doctors have expressed their discontentment about the traditional methods of drug delivery. Imbued with several limitations, the traditional methods of drug delivery failed to act in long bandwidths. From the standpoint of sustainability and affordability, traditional plastic multi-well plates are turned into intelligent devices with multi-core processing power. These devices can be programmed and updated from time to time. The ultimate goal is to disseminate cures for diseases, quickening the pace of delivery, thereby enhancing readiness. This can be labelled as a significant and imperative disruption of the traditional paradigm while maintaining cost-effectiveness and sustainability.
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Nvidia Towards Being The First Trillion Dollar Ai Chip Company
NVIDIA is the leading AI chip company. It has experienced a significant surge in its stock price, reaching an all-time high following its impressive performance in the fiscal first quarter and its optimistic forecast for future growth. The company’s predictions for the current quarter, with sales projected at $11 billion, represent a remarkable 64% year-over-year increase. This exceeded analysts’ expectations of $7.2 billion for the fiscal second quarter. The increasing demand for artificial intelligence (AI) technology is the extraordinary story propelling NVIDIA’s stock surge. CEO Jensen Huang revealed that the company is scaling production to meet the massive need for AI technology. It includes its industry-leading graphics processing units (GPUs). NVIDIA’s commitment to meeting the surging demand has captured investors’ attention, driving the stock to new heights.
Also Read: Revolutionizing Computer Graphics: NVIDIA to Unveil 20 AI Research Papers at SIGGRAPH 2023
Record-Breaking Performance and Soaring Stock PriceNVIDIA stock witnessed a staggering 24.4% surge, closing at $379.80 and peaking at $394.80 during intraday trading—a remarkable 29% increase. This surge propelled the stock past its previous record high of $346.47 in November 2023. Year to date, NVIDIA stock has already soared by an impressive 109% as of the last day’s close.
Also Read: US Stock Market Finds Boost From Artificial Intelligence (AI)
Positive Impact on Taiwan Semiconductor Manufacturing Company (TSMC)NVIDIA’s success had a positive ripple effect, extending to its contract chipmaker, Taiwan Semiconductor Manufacturing (TSM). TSM stock experienced a significant boost of 12% to $100.95 following the news of NVIDIA’s stellar performance.
Also Read: How Did A Taiwanese Company Become The Backbone Of Modern AI?
Analysts Raise Price Targets and Predict Trillion-Dollar ValuationAfter NVIDIA’s special beat-and-raise report, more than two dozen Wall Street analysts raised their price targets for NVIDIA stock. Several analysts even predicted that NVIDIA could become the next company to achieve a market value of $1 trillion. As of the close of Thursday’s trading session, NVIDIA boasted a market capitalization of $938 billion. Thus, solidifying its position as a prominent player in the market.
The Role of GPUs in NVIDIA’s SuccessLearn More: CPU vs GPU: Why GPUs are More Suited for Deep Learning?
AI Powers NVIDIA’s Data Center SegmentNVIDIA’s data center segment, encompassing semiconductors used in data centers, AI applications, and cloud computing, proved to be the star performer. The detail achieved record-breaking revenue of $4.28 billion, marking a remarkable 14% year-over-year increase and an 18% sequential increase. The robust results were primarily driven by the growing demand for generative AI and large language models utilizing NVIDIA GPUs for AI. Strong demand from large consumer internet companies and cloud service providers further contributed to the segment’s success.
Astounding Forecast and Investing ConsiderationsNVIDIA set a new high watermark for its data center segment and provided a mind-boggling forecast. Management expects revenue to reach $11 billion in the current quarter. Thus, representing a remarkable 33% year-over-year growth and potentially becoming NVIDIA’s best quarter ever. However, potential investors must consider the lofty valuation. The stock trades at 164 times trailing earnings and 27 times sales, which may deter value investors seeking more conservative multiples.
Our SayNVIDIA’s exceptional performance in the fiscal first quarter, driven by the skyrocketing demand for AI technology, has propelled its stock price to record-breaking levels. The company’s optimistic forecast and dominance in the graphics processing unit (GPU) market have garnered significant attention from investors and analysts. While the lofty valuation may raise caution for some, NVIDIA’s position as a technological leader and its ability to meet the growing demand for AI technology make it a formidable player in the industry. With a strong foundation and promising prospects, NVIDIA, an AI chip company, is well-positioned for continued growth and success in the evolving world of artificial intelligence.
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Is Discovery Plus Worth It?
No matter what 2023 has in stock, you will definitely not be deprived of interesting content to watch. With a new streaming platform in the form of Discovery Plus, cord-cutters can start relying less on television for their dosage of Discovery network shows. If you have been pondering about whether to spend that extra money on another streaming platform then let us help you make an informed decision.
What is Discovery Plus?
The Discovery family of networks has a new home in the form of the Discovery Plus streaming platform. Non-fiction shows from the network have been made available in a single place. Discovery programming lovers can enjoy rewatching their favorite shows on the platform.
To subscribe you need to pay for the ad-free or with ad pack.
How much is the Discovery Plus subscription?
Irrespective of the subscription package you choose, the content will be the same. There is no exclusive content for the $6.99 pack that is unavailable for the $4.99 subscription. Ads are the only difference between the packs.
Is it possible to get Discovery Plus for free?
Before you do go spending your hard-earned money on the subscription, let us inform you that you can get the ad-free subscription for free.
We are not talking about the seven-day free trial you get on signing up for the platform.
Discovery has partnered with Verizon to give pre-existing as well as new users the chance to get a free subscription. The span of the free subscription period depends on the Verizon connection/pack you have.
Existing Verizon Unlimited users can get the offer if they have Start Unlimited, Do More Unlimited, Get More Unlimited, or Play More Unlimited packs.
New users of Verizon Fios and 5G Home are also eligible for a year of free Discovery Plus ad-free subscription depending on their plans.
Is it possible to cancel the Discovery Plus subscription?
Discovery Plus is not a quicksand that you cannot escape from.
You can easily cancel your Discovery Plus subscription. The cancellation can be done:
From Discovery Plus website
From your iOS or Andriod device
From the Amazon website or app
From the Verizon website
When you do cancel the subscription you can continue streaming till the end of your billing period.
Which platforms support Discovery Plus?
Discovery Plus can easily be accessed from a range of devices much like the other popular streaming platforms. Since its launch on January 4, the Discovery Plus app has been compatible with a plethora of platforms.
Using your computer you can visit the Discovery Plus website, log in, and start streaming.
The Discovery Plus App can be downloaded for streaming on:
iOS devices
Andriod devices
Apple TV
2023 and onwards models of Samsung TV
Amazon Fire TV
Roku
Chromecast with Google
Google Chromecast and devices with Chromecast in-built
Microsoft Xbox- Xbox One, Series S, and Series X
While the platform is not collaborating with cable or satellite television service providers, viewers can still watch Discovery Plus on their televisions. Amazon Prime Video Channels will also soon support the streaming platform.
What content does Discovery Plus have?
When it comes to content you will definitely love the library that Discovery Plus has.
At its launch, the platform had over 55,000 episodes from more than 2,500 shows. Non-fiction shows and reality shows ranging from natural history to lifestyle are available for subscribers. Shows like 90 Days Fiance, Magnolia Table with Joanna Gaines, Mythbusters, Ghost Adventures: Cecil Hotel, The Deadliest Catch, Property Brothers, and many more have become available on the platform. The library boasts older episodes of fan-favorite shows as well as exclusive content from Discovery.
By visiting their website you can get a glimpse of all the shows that are there. However, to get a more conclusive idea of the list of shows you can start the free trial.
Are Live shows available on Discovery Plus?
A lot of people have been confused about the existence of Discovery Plus and how it affects Discovery Go and discovery network channels on television. Are you curious about which shows are moving to Discovery Plus?
So far, it seems that none of the shows will be “moving” from television to the platform.
This is because Discovery Plus does not support live streaming. The new episodes of ongoing shows will not be available on the platform. Discovery Plus will have all the episodes of older shows and exclusive content. But if you are looking to keep up with your on-going shows then you may have to wait a while for them to be added to the platform’s library.
Discovery Go is the app that supports live streaming of Discovery network shows. So, if you want to watch the latest episodes of on-going shows then you can log onto Discovery Go with your cable/satellite service provider’s details. The episodes of on-going shows are added to Discovery Go within hours of their television premiers.
However, it has remained fairly unclear if popular shows will be eventually moved from television to Discovery Plus sometime soon. It has become clear that shows on the upcoming channel, Magnolia Network, will not be on television. Time will tell if popular shows will be live-streamed exclusively.
Is Discovery Plus worth it?
So, at an additional cost of $4.99/$6.99 for a platform where you cannot keep up with the latest episodes of Discovery shows, is Discovery Plus worth it?
The answer depends totally on you…
If you want to go back and enjoy a rich library full of Discovery network’s shows from all 15 of their associated channels then it is definitely worth it.
If you want to watch shows on Magnolia Network, which is apparently exclusively on Discovery Plus, then the subscription is a must-have.
If you want a peek at exclusive content from BBC in association with Discovery then you have to subscribe.
If you are sick of formulaic movies and shows that Netflix and Amazon Prime keep pushing out, and want some refreshing reality-based content then Discovery Plus is the way to go.
It is also unclear if your beloved show will be pulled from television to Discovery Plus. So, you can plan ahead and get subscribed.
In conclusion, if the content on the platform is your binge material then it is definitely worth the free trial before the paid subscription.
Netizen’s verdict!
Since the announcement of a new platform by Discovery, there has been a mixed response from the netizens. While some chord cutters have rejoiced the additional platform’s release, many Discovery faithful have not been pleased with the paid platform’s existence.
This Twitter user was glad to get their favorite show at their convince:
— Cindy (@CindyLa98195889) January 11, 2023
This Reddit user calculated how Discovery Plus in combination with other streaming platforms would help them save money:
This Twitter user seemed simply happy with the exclusive content on the platform:
Everything is right in the world when watching David Attenborough narrate any documentary. I love everything about these nature docuseries! Ahhhh, kid at a candy store feels @discoveryplus #aperfectplanet #DavidAttenborough
— easypeasy (@picklebackshotz) January 11, 2023
These users however were pretty unhappy with having to pay for exclusive 90 Days Fiance content:
I’m so angry about this ! Get new content for your stupid new streaming channel. We’ve loyal fans now we can’t see the traditional end “ the tell all” unless we pay!?!? It’s going to be hard but I guess I’m going to stop watching
— Comeonpeople (@Frankie72913734) January 9, 2023
#ExpeditionBigfoot is moving new episodes to @discoveryplus.
Well, guess I won’t be watching anymore.
Good program, but definitely NOT worth $5 a month.
What are you thinking?
— Fermin Padilla III (@fpadillaIII) January 11, 2023
Another Reddit user pointed out that Discovery Plus subscribers are yet to get access to recent episodes of shows:
A bunch of unhappy Discovery viewers took to Twitter to complain:
My cable bill is a car payment and discovery wants more $$ no thanks!
— Pat in NoCal (@Patrick80952101) January 11, 2023
— Nette (@MsNette71) January 11, 2023
— Pat McEvoy (@PatMcEvoy6) January 11, 2023
At least Discovery Plus has been a weirdly positive addition to some lives-
So far this year I’ve cut my own hair and subscribed to Discovery Plus so I can constantly have ghost hunting shows on in the background of my life. Things are going great.
— Jess (@Circus_Macabre) January 11, 2023
How To Go Live On Tiktok: A Step By Step Guide
The TikTok LIVE feature isn’t new to social media platforms. It’s a feature Facebook, Instagram, and Twitch already have.
Simply put, it’s called livestreaming.
Here’s why you should be excited to test it out.
TikTok was the most downloaded platform in the first three months of 2023, and with its 1 billion monthly active users, there’s no denying that TikTok is taking over more feeds with its easy-to-use, short-form video format.
Aside from granting creators worldwide a chance to go viral, some users report using TikTok as a viable search engine vs. Google.
Creators and brands alike can attract more viewers and keep them captivated with TikTok’s powerful features.
Going live on TikTok takes things a step further, as you can neither edit nor script your video in real-time.
It offers a chance to truly connect with your followers.
However, not everyone can go live on TikTok. Your account needs to meet a required number of followers to use the feature.
So, how do you get a live video going?
Whether you’re an individual influencer or part of a social media team for a brand, here’s how to set up your first ever TikTok LIVE with this detailed, step-by-step guide.
Here’s what you need to know.
What Is TikTok LIVE?TikTok LIVE is just as it sounds – it’s a live video feature that lets you engage in real-time with your audience.
In May 2023, TikTok introduced a limited version of LIVE Subscription – a monthly subscription where fans can show appreciation for their favorite live creators with custom emotes, subscriber badges, and subscriber-only chats.
Additional features will be rolled out gradually worldwide in the next few months as it becomes available to more creators (the offering was initially invite-only).
Requirements For Going Live On TikTokBefore we jump right into it, here are the requirements for TikTok LIVE:
Tiktok only allows this feature for accounts with over 1,000 followers. Those with fewer followers can try their luck, but it might not work.
Creators must be at least age 16 for legal reasons and can only earn money if aged 18 and up, per the platform’s community guidelines.
TikTok LIVE: Key Features To NoteOnce you’re eligible, here’s a rundown of the official features to maximize your use of TikTok LIVE.
More features are being added, but here’s what we know so far:
Go LIVE together: People can “go live” simultaneously, fostering more authentic and funny moments.
Q&A: A special suite of tools help creators seamlessly select, answer, or showcase questions during the event.
Live Events notifications: Hosts can promote, schedule, and manage live events like concerts. Notifications will alert fans before the event, so they don’t miss the action.
Gifts: What’s in it for hosts? Those over 18 can enjoy LIVE gifts or Diamonds, which are given by viewers and convertible to cash in your PayPal or bank account.
Here’s How To Set Up And Schedule Your LiveOpen the app and tap the create icon (+).
Slide and select LIVE from the bottom of the menu.
Select a cover pic and a title (32 characters) – make sure it’s eye-catching!
Then tap: “Go LIVE,” which immediately alerts your followers.
End the livestream by tapping the X on the top left-hand corner of your screen.
That’s it! The steps are pretty simple and intuitive.
Pick A Relevant Topic For Your TikTok LiveGoing live might be less edited and more spontaneous, but it’s best to come prepared.
To ensure viewer interest in your first LIVE experience, try looking at the TikTok Insight Tool to see how different demographics respond to holidays, industries, and more.
It doesn’t hurt to make sure you know your well-defined audience and how they feel about certain brands and content.
Discovery is where TikTok truly shines; observe how TikTok recommends videos for the Following feed, Search results, and Friends tab, and find a way that works for your brand.
There are a lot of creative formats you can play with.
TikTok Live Tips Best Practices/TipsWhen it comes to livestreaming, best practices always apply. TikTok recommends the following:
Great lighting – Grainy just won’t do. It helps to have a good tripod and LED light or ring light set up so your viewers can see what’s happening from start to finish.
Eliminate distracting sounds – As much as possible, avoid livestreaming while there’s ongoing construction or loud background noises. Consider a microphone with noise isolation or moving to a quieter area.
Pick a good camera angle – Record in a room with a clean and solid background. Set your device on a stable surface, like a table, and pick a flattering camera angle. Note that TikTok’s software is optimized for vertical focus.
Test your internet connection – The last thing you want is a choppy live session. Double (or triple) check your connection speed before the event.
Come up with a general plan – Awkward moments happen, but you can avoid long pauses and extend the duration of your livestream by writing down a few bullets of what you’ll do. Have an outline or a general idea of what the video will look like from start to finish. (Tip: Avoid a formal script since that defeats the purpose of connecting with viewers organically.)
Cross-promote on other platforms – Not all your followers are on TikTok, but inviting them to the platform can make a big difference. Use Facebook, Instagram, and your other social platforms to announce your TikTok LIVE event.
TakeawaysNow that you understand how to use TikTok LIVE, you can start leveraging the tool to reach your audience on the platform.
When done right, live content can help you connect on a deeper level with your audience because it lets you provide them with a more spontaneous and immersive experience.
Plus, it often feels more personal.
Observe what the top creators are doing and why they’re relatable to audiences.
Keep in mind that different personalities suit different categories.
See how Instagram Reels, Facebook Live, and other platforms differ in terms of best practices when it comes to engagement. Deepen your understanding of what works on each platform, and keep adapting your material to better suit each one.
The TikTok platform tends to showcase more personable content, so livestreaming may be your best bet when it comes to busting industry myths, displaying a sense of humor, going behind the scenes, collaborating with influencers, or using trending sound clips that resonate with your target audience.
Lastly, don’t forget to have fun!
More resources:
Featured Image: DDimaXX/Shutterstock
A ‘Living’ Cancer Drug Helped Two Patients Stay Disease
In 2010, three patients received an experimental form of immunotherapy for leukemia through a clinical trial at the University of Pennsylvania. Two of the patients went into complete remission—and stayed that way.
The treatment, known as CAR T-cell therapy, is now FDA-approved to treat certain blood cancers. It involves engineering a patient’s own white blood cells to attack cancerous cells and then returning them to the body. Since clinical trials and FDA approval, CAR T-cell therapy has already been used to successfully treat and clear certain cancers. However, CAR T-cell therapy doesn’t lead to lasting remissions for every patient, and it can cause serious side effects. A new report offers clues about why the treatment is sometimes remarkably effective.
The two patients who responded well to CAR T-cell therapy in 2010 remained disease free for over a decade. One of the men, a Californian named Doug Olson, is now 75. The other, William Ludwig, died early last year of COVID-19. Researchers were able to detect CAR T-cells lingering in Olson and Ludwig’s bloodstreams long after their cancers disappeared, although the types of immune cells that persisted were slightly different than anticipated, the team reported on February 2 in Nature.
“Now we can finally say the word ‘cure’ with CAR T-cells,” Carl June, the principal investigator for the University of Pennsylvania trial, told The New York Times.
Olson and Ludwig were among the earliest recipients of CAR T-cell therapy, allowing clinicians a chance to track the patients’ cells and condition over the past decade. “To use the word ‘cure,’ you really need a long time to follow up to make sure people don’t relapse,” says David Maloney, the medical director of cellular immunotherapy at the Immunotherapy Integrated Research Center at the Fred Hutchinson Cancer Research Center in Seattle. “When we get these people out to 10 and 11 years post-treatment, that encourages us to be a little more forceful in saying that perhaps patients are cured in some cases.”
While it may be too soon to know for certain that these patients are cured, Rosenberg feels, these cases are all very encouraging. “I think it’s a good step in that direction,” he says. “It certainly can last a very long time and provide a relatively normal life back to these patients.”
A living drugImmunotherapy treatments harness a person’s immune system to fight cancer. The white blood cells known as T-cells, which form the basis of CAR T-cell therapy, play a variety of roles in the immune system, including attacking cells that have become infected by viruses or turned cancerous. However, the T-cells a person’s body makes naturally may not be equipped with the recognition tools, or may be too few in number, to vanquish their cancer.
The goal of CAR T-cell therapy is to genetically modify T-cells so they can effectively destroy cancerous cells. T-cells are edited to produce a lab-designed protein called a chimeric antigen receptor, or CAR, on their surface. The CAR is tailored to the type of cell that has gone awry. “[You] essentially insert a gene that could make all of the T-cells recognize the same thing,” Maloney says.
[Related: Why immunotherapy could be the cure to cancer we have all been waiting for]
For the clinical trials in 2009 and 2010, Rosenberg’s team and the University of Pennsylvania researchers independently engineered CAR T-cells that home in on a molecule called C19 that’s found on antibody-making B-cells—another immune cell known to become cancerous in certain leukemias and lymphomas. After being administered, the disease-fighting T-cells can multiply by up to 10,000 times over the course of several weeks, Rosenberg says. The patient is treated with their own cells.
“It’s a living drug,” Rosenberg says. “They can survive in the body for years, and they appear to be able to mediate complete, durable [remissions].”
CAR T-cell therapy is now used to treat certain forms of leukemia, lymphoma, and multiple myeloma. But, as the Times noted, it’s more effective against some blood cancers than others. Some people who go into remission later relapse.
To understand why CAR T-cell therapy was so successful for Olson and Ludwig, June and his colleagues investigated the fate of the modified cells. “The surprising thing is that the types of CAR T-cells that actually persisted seemed to be slightly different than what people were anticipating would be the ones that would result in a long-term population,” Maloney says.
The cells that stuck around weren’t the so-called “killer” T-cells that attack diseased cells, but rather “helper” T-cells that are typically involved in coordinating the immune response. Laboratory experiments suggested that, intriguingly, these helper CAR T-cells retained their cell-killing ability.
“We have long realized that there must be differences between CAR T-cells that persist for long periods and those that die within weeks to months from exhaustion,” John E. Levine, a professor of medicine, hematology, and medical oncology and of pediatrics at the Tisch Cancer Institute at Mount Sinai in New York, said in an email. “This paper now defines some of those differences.”
The reason for the lasting response, he said, may be that the CAR T-cells are kept stimulated by the B-cells constantly being made in the bone marrow. “These B-cells provide an endless source of targets for the few CAR T-cells that have the potential to stay healthy and live a long time,” Levine said.
“This entirely new approach of creating a drug for the patient using their own cells has resulted in these dramatic long-term responses that have returned people from being very ill to normal life and certainly is here to stay.”
— Steven Rosenberg, National Cancer Institute’s Center for Cancer Research
The results could help researchers identify CAR T-cell traits to emulate in the future. “This will lead to a lot of additional work to see how these cells arise and evolve over time after they’re infused,” Maloney says, adding that research clinicians could “potentially make cells that have these characteristics that might be associated with better outcomes.”
Another possible avenue for CAR T-cell research is to recreate the conditions that set these immune warriors up for success when they don’t occur naturally. For example, Levine said, researchers could “provide an artificial source that mimics the constant stimulation of CAR T-cells that seems to help keep them surveilling for malignant cells.”
Understanding more about how these treatments work could ultimately lead to patients receiving CAR T-cell therapy without having to wait until several other lines of treatment have failed. “As we get more data [and] we know how safe they are, we know how effective they are, we can start moving them up, and the future may be that this will be used much earlier in the course of cancer therapy than where we’re currently using them,” Maloney says.
Broadening the approachOne major drawback of CAR T-cell therapy is that it hasn’t been proven effective against solid tumors found in places like the colon, stomach, prostate, breasts, and uterus, which cause about 90 percent of cancer deaths in the US, Rosenberg says.
There are several reasons for this: “It’s a hostile environment, where the tumor is trying to kill the T-cells and trying to keep the T-cells out of the tumor so they…can’t actually get in there and attack the cancer,” Maloney says. Researchers are working on strategies to make T-cells more resistant to these blocking efforts, he says.
Another problem is that CAR T-cells kill healthy cells along with cancerous ones. When CAR T-cells demolish B-cells in people with blood cancers, the immune system can become more vulnerable to infections. To help avoid this, patients can receive antibody infusions and their antibody-making B-cells may replenish over time, Rosenberg says.
With solid tumors it’s a different story. “You can live without B-cells during that interim by getting immunoglobulin infusions, whereas if you wipe out a liver or a lung or a heart or a brain, you can’t survive,” he says.
Fortunately, solid tumors are often somewhat vulnerable to naturally occuring T-cells, which recognize abnormal proteins specific to these cancerous cells. “The DNA in the normal cells has mutated in these solid cancers…and it turns out it’s the products of those mutations that conventional T-cells recognize,” Rosenberg says.
He and his colleagues have spent several decades investigating treatments that are similar in principle to CAR T-cell therapy to fight solid cancers.
One approach involves identifying which T-cells are best at recognizing a person’s cancer, multiplying these tumor-invading cells to much greater numbers in the lab, and transferring them back into the patient. Melanoma is a particularly appealing target for this treatment because it tends to have many mutations for T-cells to recognize. However, the experimental therapy shows promise for other types of cancer as well, including metastatic breast cancer.
The team is also testing techniques aimed at patients who don’t mount a strong enough immune response on their own. T-cells from these people are engineered to carry lab-made versions of naturally occurring T-cell proteins that will recognize mutations found on their cancer, much like CAR T-cells are equipped with synthetic proteins.
These treatments can be more complicated to implement than CAR T-cell therapy because the T-cells recognize solid tumors by mutations that differ from one patient to the next, rather than a common molecule like CD19. “It’s a very highly personalized treatment, but we’ve shown it can be effective,” Rosenberg says. “The major challenge that we face now is increasing it from isolated cases to treatments that can be widely administered.”
The treatments he and his team are working on and CAR T-cell therapy are all forms of adoptive cell therapy, a branch of immunotherapy that involves multiplying or engineering immune cells from a patient to fight their cancer. The most promising avenue for adoptive cell therapy, Rosenberg feels, will be against the solid tumors in the future
“This entirely new approach of creating a drug for the patient using their own cells has resulted in these dramatic long-term responses that have returned people from being very ill to normal life and certainly is here to stay,” Rosenberg says.
Intel Edison Step By Step
This is an introductory level course on Intel Edison. This course is designed for absolute beginners makers. We have come up with an Introductory course on Intel Edison in which will show you how to get started from the basic level of this cool single board computer. The course requires basic knowledge of Arduino programming language. We’ll help you to get started with the basics of setting up and installation process and also creating circuits with the Intel Edison board.
In this course will show you how to use Intel Edison for the first time and how to use Flex sensor with LED, Servo motor, Buzzer and also to control power of light using the serial-3-channel-ac-230v light dimmer module using multiple Flex sensors. Intel Edison and its development board are also very interesting.
We makers love microcontrollers a lot! The endless possibilities that these pieces of hardware give to us. Ever wondered how small they keep getting. A board is so small that it removes huge barriers in the world of wearables and the Internet of Things! It’s the Intel Edison Board. This Introduction to Intel Edison for beginner’s course will show you how to get started on working with this cool single board computer.
On one way, you can use this board as Arduino with its shields; these are suitable easily. On the other hand, you can connect your board via Wi-Fi to get on the internet.
The Intel Edison board is a cool single computer board platform that helps you build amazing stuff just like the Arduino board. Here, you can use platforms like Arduino, Eclipse for working on it. This board uses an Intel Atom processor with a dual-core CPU at 500 MHz and a microcontroller at 100 MHz.
The Edison board sports 1GB of memory, 4GB of storage and even has Wi-Fi and Bluetooth 4.0 capabilities. It also has 40 GPIOs for plugging in all sorts of crazy sensors and motors you can think.
The module of Intel named Intel Edison is slightly larger than an SD card. After playing around with Edison. The specialty of Edison is that it can use for wearables, and it is powerful enough to control robots. This module equipped with Yocto, a Linux OS. It has an onboard Wi-Fi and Bluetooth, perfect for IoT projects. We can connect to Edison remotely and run commands or access the file system. It gives lots of flexibility to developers via SSH.
The prerequisite for this course is a basic understanding of electrical and electronic concepts and ability to download and install software on your computer. Along the way, you will learn about programming, sensors, and communications.
The goal of this project is to create a wearable glove integrated with flex sensors so that as the wearer bends his/her fingers it translates to a quantitative value on the circuit board. The goal is that when you bend your fingers, we can control the 230V of light dimmer.
If you are a technology enthusiast and want to learn the cutting-edge technology, then this is the right course for you. In this course, I will show you how to get up and running on the Intel Edison platform so you can do your projects to interact with the world.
I will teach you step by step how to go about building this project. I will also share the code with you so that you can replicate the project yourself. I look forward to you joining this course. It provides the complete source code of the real time project.
What are you waiting for? Enroll now.
Who this course is for:
People who want to learn Intel Edison from the basic and microcontrollers
Makers who have an existing intermediate or better understanding of electronics
Individuals wanting to learn more about controlling the power of 230V using the light dimmer module
Engineering Students – Electronics, Electrical & Computer Science
Electronic Geeks, Hobbiest & Art Students
High School Science Students
Goals
Start with the Introduction to Intel Edison for beginner’s to get started on working with this cool single board computer
Control the power of light using the Serial-3-channel-ac-230v light dimmer module
Control Servo motor using Flex sensor
Calibrate the Flex sensor range values
Use Flex sensor to fade an LED
Control the tone of Buzzer using Flex sensor
Prerequisites
You would need to download the Intel Edison and Arduino IDE software
Intel Edison board
3 x Flex sensor, 1 x breadboard, 3 x 10k ohm resistor, 1 x Buzzer, 1 x LED, 1 x Servo motor
1 x Serial 3 channel AC 230v SSR and Dimmer
Thin wires to solder and jumper wires
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